2021
Murine Model of Sinusitis Infection for Screening Antimicrobial and Immunomodulatory Therapies. Alford, M.A., Choi, K.G., et al. Frontiers. 2021 March 12. doi: https://doi.org/10.3389/fcimb.2021.621081
Brain injury after 50 h of lung-protective mechanical ventilation in a preclinical model. Bassi, T.G., Rohrs, E.C., Fernandez, K.C. et al. Sci Rep. 2021 March 3. doi: https://doi.org/10.1038/s41598-021-84440-1
Early overnutrition in male mice negates metabolic benefits of a diet high in monounsaturated and omega-3 fats. Glavas, M.M., Hui, Q., Miao, I. et al. Sci Rep. 2021 July 7. doi: https://doi.org/10.1038/s41598-021-93409-z.
Role of adipocyte Na,K-ATPase oxidant amplification loop in cognitive decline and neurodenegeration. Komal Sodhi, Rebecca Pratt, et al. iScience. 2021 Oct 12. doi: https://doi.org/10.1016/j.isci.2021.103262.
2020
In vivo Anti-inflammatory Activity of Lipidated Peptidomimetics Pam-(Lys-βNspe)6-NH2 and Lau-(Lys-βNspe)6-NH2 Against PMA-Induced Acute Inflammation. Wu BC, Skovbakke SL, Masoudi H, Hancock REW and Franzyk H. Front. Immunol. 2020 Aug 28. doi: 10.3389/fimmu.2020.02102
Functional cytochrome P450 1A enzymes are induced in mouse and human islets following pollutant exposure. Ibrahim, M., MacFarlane, E.M., Matteo, G. et al. Diabetologia. 2020 Jan. doi:10.1007/s00125-019-05035-0
AAV8 Ins1-Cre can produce efficient β-cell recombination but requires consideration of off-target effects. Ramzy, A., Tudurí, E., Glavas, M.M. et al. Sci Rep. 2020 June 29. doi:10.1038/s41598-020-67136-w
Revisiting Proinsulin Processing: Evidence That Human β-Cells Process Proinsulin With Prohormone Convertase (PC) 1/3 but Not PC2.
Distinct Functional Requirements for Podocalyxin in Immature and Mature Podocytes Reveal Mechanisms of Human Kidney Disease. Refaeli, I., Hughes, M.R., Wong, A.K. et al. Sci Rep. 2020 June 10;9419. doi: 10.1038/s41598-020-64907-3.
Rorqual whale nasal plugs: protecting the respiratory tract against water entry and barotrauma.
2019
Intravenous immunoglobulin (IVIg) or IVIg-treated macrophages reduce DSS-induced colitis by inducing macrophage IL-10 production. Kozicky LK, Menzies SC, Hotte N, Madsen KL, Sly LM. Eur J Immunol. 2019 May 17;49(8):1251-1268. doi:10.1002/eji.201848014.
Pancreas-specific miR-216a regulates proliferation and endocrine and exocrine cell function in vivo. , , , , , , , , , , , , , , 2019 Oct 7.
Metabolic Syndrome and Salt-Sensitive Hypertension in Polygenic Obese TALLYHO/JngJ Mice: Role of Na/K-ATPase Signaling. Yan Y, Wang J, Chaudhry MA, et al. Int J Mol Sci. 2019 Jul 16. doi:10.3390/ijms20143495.
Early overnutrition reduces Pdx1 expression and induces β cell failure in Swiss Webster mice. Glavas MM, Hui Q, Tudurí E, Erener S, Kasteel NL, Johnson JD, Kieffer TJ. Sci Rep. 2019 Mar 6;9(1):3619. doi: 10.1038/s41598-019-39177-3.
2018
Carbamazepine, a beta-cell protecting drug, reduces type 1 diabetes incidence in NOD mice. Lee, J.T.C., Shanina, I., Chu, Y.N. et al. Sci Rep. 2018 Mar 15;4588. doi:10.1038/s41598-018-23026-w
Insulin-Deficient Mouse β-Cells Do Not Fully Maturebut Can Be Remedied Through Insulin Replacement by Islet Transplantation. Ramzy A, Mojibian M, Kieffer TJ. Endocrinology. 2018 Jan 1;159(1):83-102. doi: 10.1210/en.2017-00263.
Ozanimod (RPC1063), a selective S1PR1 and S1PR5 modulator, reduces chronic inflammation and alleviates kidney pathology in murine systemic lupus erythematosus. Taylor Meadows KR, Steinberg MW, Clemons B, Stokes ME, Opiteck GJ, Peach R, Scott FL. Plos One. 2018 April 2. doi: 10.1371/journal.pone.0193236
Histology of resin vehicles and oleoresin terpene composition of conifer seeds. Kshatriya K, Whitehill J, Madilao L, Henderson H, Kermode A, Kolotelo D, Bohlmann J. Canadian Journal of Forest Research. 2018 Jun 26. doi: 10.1139/cjfr-2018-0164.
Adipose Tissue Expression of PACAP, VIP, and Their Receptors in Response to Cold Stress. Cline D, Short L, Forster M, Gray S. Journal of Molecular Neuroscience. 2018 Jul 7. doi: /10.1007/s12031-018-1099-x.
Interactive effects of salinity and temperature acclimation on gill morphology and gene expression in threespine stickleback. Comparative Biochemistry. Gibbons T, McBryan T, Schulte P. 2018 July. doi: 10.1016/j.cbpa.2018.03.013
Image Analysis and histochemistry to identify mobile stem resources for seed production in soybean. Alerding A, Irvine M, Cunicelli M, Waalkes M, Hill E, Rowe R. Journal of Crop Improvement. 2018 Aug 2. doi: 10.1080/15427528.2018.1502705
Pilot Study to Evaluate the Association Between the Length of the Luteal Phase and Estrous Activity Detected by Automated Activity Monitoring in Dairy Cows. Denis-Robichaud J, LeBlanc S, Jones-Bitton A, Silper B, Cerri R. Front Vet Sci. 2018 Aug 31. doi: 10.3389/fvets.2018.00210.
2017
Lipid nanoparticle delivery of glucagon receptor siRNA improves glucose homeostasis in mouse models of diabetes. Neumann UH, Ho JSS, Chen S, Tam YYC, Cullis PR, Kieffer TJ. Mol Metab. 2017 Oct;6(10):1161-1172. doi:10.1016/j.molmet.2017.06.012
Rapid melanoma induction in mice expressing oncogenic BrafV600E using Mitf-cre. Urtatiz O, Samani AMV, Kopp JL, Van Raamsdonk C. Pigment Cell Melanoma Res. 2017 Dec 20. doi: 10.1111/pcmr.12680.
Magnetically-actuated drug delivery device (MADDD) for minimally invasive treatment of prostate cancer: An in vivo animal pilot study. Struss WJ, Tan Z, Zachkani, Moskalev I, Jackson JK, Shademani A, D’Costa N, Raven P, Frees S, Chavez-Munoz C, Chiao M, So A. Prostate. 2017 May;77(13):1356-1365. doi: 10.1002/pros.23395.
Efficacy of Postnatal In Vivo Nonsense Suppression Therapy in a Pax6 Mouse Model of Aniridia. Wang X, Gregory-Evans K, Wasan KM, Sivak O, Shan X, Gregory-Evans CY. Mol Ther Nucleic Acids. 2017 Jun 16;7:417-428. doi: 10.1016/j.omtn.2017.05.002.
Restoration of Lepr in β cells of Lepr null mice does not prevent hyperinsulinemia and hyperglycemia. D’souza AM, Kieffer TJ. Mol Metab. 2017 Apr 11;6(6):585-593. doi: 10.1016/j.molmet.2017.04.003.
Age at injury and genotype modify acute inflammatory and neurofilament-light responses to mild CHIMERA traumatic brain injury in wild-type and APP/PS1 mice. Cheng WH, Stukas S, Martens K, Namjoshi D, Button E, Wilkinson A, Bashir A, Robert J, Cripton P, Wellington C. Experimental Neurology. 2017 Dec 18. doi: 10.1018/j.expneurol.2017.12.007
Stem growth during seed production in soybean: Implications for pod yield. Alerding A, Waalkes M, Hill E, Rowe R, Parsons G. Journal of Crop Improvement. 2017 Dec 19. doi: 10.1080/15427528.2017.1381866
2016
Small Intestine Early Innate Immunity Response during Intestinal Colonization by Escherichia coli Depends on Its Extra-Intestinal Virulence Status. Tourret J, Willing BP, Croxen MA, Dufour N, Dion S, Wachtel S, Denamur E, Finlay BB. PLoS One. 2016 Apr 20;11(4):e0153034. doi: 10.1371/journal.pone.0153034.
Astrocytes promote glioma invasion via the gap junction protein connexin43. Sin WC, Aftab Q, Bechberger JF, Leung JH, Chen H, Naus CC. Oncogene. 2016 Mar 24;35(12):1504-16. doi: 10.1038/onc.2015.210.
2015
The Human Dental Pulp Proteome and N‑Terminome: Levering the Unexplored Potential of Semitryptic Peptides Enriched by TAILS to Identify Missing Proteins in the Human Proteome Project in Underexplored Tissues. Eckhard U, Marino G, Abbey SR, Tharmarajah G, Matthew I, Overall CM. J Proteome Res. 2015 Sep 4;14(9):3568-82.
Self-propelled particles that transport cargo through flowing blood and halt hemorrhage. Baylis JR, Yeon JH, Thomson MH, Kazerooni A, Wang X, St John AE, Lim EB, Chien D, Lee A, Zhang JQ, Piret JM, Machan LS, Burke TF, White NJ, Kastrup CJ. Sci Adv. 2015 Oct 2;1(9):e1500379. doi: 10.1126/sciadv.1500379.
Podoplanin: a marker for reactive gliosis in gliomas and brain injury. Kolar K, Freitas-Andrade M, Bechberger JF, Krishnan H, Goldberg GS, Naus CC, Sin WC. J Neuropathol Exp Neurol. 2015 Jan;74(1):64-74. doi: 10.1097/NEN.0000000000000150.
2014
Overexpression of PAX4 reduces glucagon expression in differentiating hESCs. Gage BK, Baker RK, Kieffer TJ. Islets. 2014;6(2):e29236. doi: 10.4161/isl.29236.
Irinophore C™, a lipid nanoparticle formulation of irinotecan, abrogates the gastrointestinal effects of irinotecan in a rat model of clinical toxicities. Waterhouse DN, Sutherland BW, Santos ND, Masin D, Osooly M, Strutt D, Ostlund C, Anantha M, Harasym N, Manisali I, Wehbe M, Bally MB, Webb MS. Invest New Drugs. 2014 Dec;32(6):1071-82. doi: 10.1007/s10637-014-0138-x.
Impairing eukaryotic elongation factor 2 kinase activity decreases atherosclerotic plaque formation. Zhang P, Riazy M, Gold M, Tsai SH, McNagny K, Proud C, Duronio V. Can J Cardiol. 2014 Dec;30(12):1684-8. doi: 10.1016/j.cjca.2014.09.019.
2013
Initial cell seeding density influences pancreatic endocrine development during in vitro differentiation of human embryonic stem cells. Gage BK, Webber TD, Kieffer TJ. PLoS One. 2013 Dec 4;8(12):e82076. doi: 10.1371/journal.pone.0082076.
Cessation of neoangiogenesis in Alzheimer’s disease follows amyloid-beta immunization. Biron KE, Dickstein DL, Gopaul R, Fenninger F, Jefferies WA. Sci Rep. 2013;3:1354. doi: 10.1038/srep01354.
Intimal thickness associated with endothelial dysfunction in human vein grafts. Li FD, Sexton KW, Hocking KM, Osgood MJ, Eagle S, Cheung-Flynn J, Brophy CM, Komalavilas P. J Surg Res. 2013 Mar;180(1):e55-62. doi: 10.1016/j.jss.2012.06.017.
2011
The Deubiquitinase Activity of the Salmonella Pathogenicity Island 2 Effector, SseL, Prevents Accumulation of Cellular Lipid Droplets. Arena ET, Auweter SD, Antunes LC, Vogl AW, Han J, Guttman JA, Croxen MA, Menendez A, Covey SD, Borchers CH, Finlay BB. Infect Immun. 2011 Nov;79(11):4392-400. doi: 10.1128/IAI.05478-11.
Comparative murine norovirus studies reveal a lack of correlation between intestinal virus titers and enteric pathology. Kahan SM, Liu G, Reinhard MK, Hsu CC, Livingston RS, Karst SM. Virology. 2011 Dec 20;421(2):202-10. doi: 10.1016/j.virol.2011.09.030.
2010
Genome-wide transcriptome analysis of the transition from primary to secondary stem development in Populus trichocarpa. Palitha Dharmawardhana, Amy M Brunner, Steven H Strauss. BMC Genomics. 2010 Mar 4;11:150. doi: 10.1186/1471-2164-11-150.
Salmonella SPI-1-mediated neutrophil recruitment during enteric colitis is associated with reduction and alteration in intestinal microbiota. Sekirov I, Gill N, Jogova M, Tam N, Robertson M, de Llanos R, Li Y, Finlay BB. Gut Microbes. 2010 Jan;1(1):30-41.
Directed evolution of a magnetic resonance imaging contrast agent for noninvasive imaging of dopamine. Mikhail G Shapiro, Gil G Westmeyer, Philip A Romero, Jerzy O Szablowski, Benedict Kuster, Ameer Shah, Christopher R Otey, Robert Langer, Frances H Arnold, and Alan Jasanoff, Nature Biotechnology, February 28, 2010, (28) 264 270.
A Role for KAI1 in Promotion of Cell Proliferation and Mammary Gland Hyperplasia by the gp78 Ubiquitin Ligase. Bharat Joshi, Lei Li1 and Ivan R. Nabi2. March 19, 2010. The Journal of Biological Chemistry (285); 8830-8839.
2009
SHIP1 is a repressor of mast cell hyperplasia, cytokine production, and allergic inflammation in vivo. Haddon DJ, Antignano F, Hughes MR, Blanchet MR, Zbytnuik L, Krystal G, McNagny KM. J Immunol. 2009 Jul 1;183(1):228-36. doi: 10.4049/jimmunol.0900427.
Altered distribution of tight junction proteins after intestinal ischaemia/reperfusion injury in rats. Li Q, Zhang Q, Wang C, Liu X, Qu L, Gu L, Li N, Li J. J Cell Mol Med. 2009 Sep;13(9B):4061-76. doi: 10.1111/j.1582-4934.2009.00975.x.
Bone Marrow-Derived Mast Cells Accumulate in the Central Nervous System During Inflammation but Are Dispensable for Experimental Autoimmune Encephalomyelitis Pathogenesis. Jami L. Bennett, Marie-Renee Blanchet, Linlin Zhao, Lori Zbytnuik, Frann Antignano, Matthew Gold, Paul Kubes and Kelly M. McNagny. Journal of Immunology 2009 (182); 5507-5514.
Lack of IL-6 during Coxsackievirus Infection Heightens the Early Immune Response Resulting in Increased Severity of Chronic Autoimmune Myocarditis. Poffenberger MC, Straka N, El Warry N, Fang D, Shanina I, et al. (2009). PLoS ONE 4(7): e6207. doi:10.1371/journal.pone.0006207
Gap junction hemichannels contribute to the generation of diarrhea during infectious enteric disease. Julian Andrew Guttman, Ann En-Ju Lin, Yuling Li, et al. GUT (International Journal of Gastroenterology and Hepatology), October 14, 2009.
2008
Metabolic adaptation in Cryptococcus neoformans during early murine pulmonary infection. Hu G, Cheng PY, Sham A, Perfect JR, Kronstad JW. Mol Microbiol. 2008 Sep;69(6):1456-75. doi: 10.1111/j.1365-2958.2008.06374.x.
A murine intraperitoneal infection model reveals that host resistance to Campylobacter jejuni is Nramp1 dependent. Olivia Championa, Yanet Valdeza, Lisa Thorsonb, Julian A. Guttmanb, Alfredo Menendezb, Erin C. Gaynora and Brett Finlay. Microbes and Infection (Volume 10, Issue 8), July 2008; 922-927.
Antibiotic-Induced Perturbations of the Intestinal Microbiota Alter Host Susceptibility to Enteric Infection. Inna Sekirov, Nicola M. Tam, Maria Jogova, Marilyn L. Robertson, Yuling Li, Claudia Lupp, and B. Brett Finlay. Infection and Immunity (Vol. 76, No. 10), October 2008; 4726-4736.
2007
Linckia multifora (Echinodermata: Asteroidea) in Rarotonga, Cook Islands: reproductive mechanisms and ecophenotypes (1). Crawford, Terry F.; Crawford, Bruce F. Pacific Science; July 1, 2007
Human matrix metalloproteinase-8 gene delivery increases the oncolytic activity of a replicating adenovirus. Cheng J, Sauthoff H, Huang Y, Kutler DI, Bajwa S, Rom WN, Hay JG. Molecular Therapy 2007 Nov;15(11):1982-90. Epub 2007 Jul 24
Murine norovirus 1 infection is associated with histopathological changes in immunocompetent hosts, but clinical disease is prevented by STAT1-dependent interferon responses. Mumphrey SM, Changotra H, Moore TN, Heimann-Nichols ER, Wobus CE, Reilly MJ, Moghadamfalahi M, Shukla D, Karst SM. Journal of Virology 2007 Apr;81(7):3251-63.
HCN2 and HCN4 isoforms self-assemble and co-assemble with equal preference to form functional pacemaker channels. Whitaker GM, Angoli D, Nazzari H, Shigemoto R, Accili EA. Journal of Biological Chemistry 2007 Aug 3;282(31):22900-9.
Human bone marrow activates the Akt pathway in metastatic prostate cells through transactivation of the alpha-platelet-derived growth factor receptor. Dolloff NG, Russell MR, Loizos N, Fatatis A. Cancer Research 2007 Jan 15;67(2):555-62.
2006
Evidence that Tight Junctions Are Disrupted Due to Intimate Bacterial Contact and Not Inflammation during Attaching and Effacing Pathogen Infection In Vivo. Julian A. Guttman, Fereshte N. Samji, Yuling Li, Wayne Vogl, and Brett Finlay. Infect Immun, 2006 November; 74(11); 6075–6084.
Markedly enhanced cytolysis by E1B-19kD-deleted oncolytic adenovirus in combination with cisplatin. Yoon AR, Kim JH, Lee YS, Kim H, Yoo JY, Sohn JH, Park BW, Yun CO. Human Gene Therapy 2006. Apr;17(4):379-90.
Attaching and effacing pathogen-induced tight junction disruption in vivo. Guttman JA, Li Y, Wickham ME, Deng W, Vogl AW, Finlay BB. Cellular Microbiology 2006 Apr;8(4):634-45.
2004
Distinct temporal activity patterns in the rat M1 and red nucleus during skilled versus unskilled limb movement. L. Hermer-Vazquez, R. Hermer-Vazquez, K. A. Moxon, K. H. Kuo, V. Viau, Y. Zhan and J. K. Chapin. Behavioural Brain Research (150), 2 April 2004; 93-107.