Histological evaluation is the preferred method for examining the in-situ interaction between implanted medical devices and its surrounding tissue. The challenge lies in maintaining the interaction between the device and tissue due to differences in density. This method will present a similar density between the materials, allowing for a clean section through the tissue, device, and the interface. We have specially developed protocols to process, section, and stain devices implanted in tissue.
With this method, it is possible to examine the changes taking place at the interaction site such as scar tissue formation, changes to tissue architecture, changes in collagen and other protein profiles, tissue infiltration into the device and inflammation. Since most medical devices differ in material, our research team will work closely with you to develop specific protocols for your studies. In general, softer devices can be sectioned and deplastinated to obtain the best staining results.