Biocompatibility of Implants/Medical Devices

Histological evaluation is the preferred method to examine the in situ interaction between the implanted device and surrounding tissues. With paraffin histology, it is difficult to maintain the device/tissue interaction when examining the interface between two materials. This difficulty arises as a result of the differences in density and material properties between the tissue and device.

Because of the separation and tissue damage caused by the device material, paraffin sections fail to represent the device/tissue interaction, normal tissue morphology, and the true nature of the tissue integration with the implanted device. One solution to this problem is processing and embedding the device and surrounding tissues in a resin material. This method will present similar density properties, allowing for sectioning through the device/tissue, while maintaining interactions.

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