Histopathological Considerations for IHC-based Studies

In any biological experiment, the quality of the data generated is directly related to the quality of the samples and methods used in the study. Ideally, animal studies are designed to include a single variable between the experimental groups. It is essential to have appropriate control groups against which data from treated groups can be compared. In studies that use an animal disease model, naïve animals constitute the usual control group. For toxicology studies, the control group typically receives the vehicle by the same route, frequency, and volume as the test article dosed groups. In medical device studies, two control groups, a group of naïve (non-implanted) animals, and a group subjected to a comparator device are useful. 

The Role of Histopathology
Histopathology is the art and science of evaluating tissue sections by light microscopy and recording the observed findings—this is primarily a process of pattern recognition. While the human eye is well adapted to pattern recognition, it is less trained to recognize the quantification of what it sees; therefore, any quantitative scoring of routine histologic sections by a pathologist is semi-quantitative at best.

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