Histopathological Considerations for IHC-based Studies
In any biological experiment, the quality of the data generated is directly related to the quality of the samples and methods used in the study. Ideally, animal studies are designed to include a single variable between the experimental groups. It is essential to have appropriate control groups against which data from treated groups can be compared. In studies that use an animal disease model, naïve animals constitute the usual control group. For toxicology studies, the control group typically receives the vehicle by the same route, frequency, and volume as the test article dosed groups. In medical device studies, two control groups, a group of naïve (non-implanted) animals, and a group subjected to a comparator device are useful.
The Role of Histopathology
Histopathology is the art and science of evaluating tissue sections by light microscopy and recording the observed findings—this is primarily a process of pattern recognition. While the human eye is well adapted to pattern recognition, it is less trained to recognize the quantification of what it sees; therefore, any quantitative scoring of routine histologic sections by a pathologist is semi-quantitative at best.
- Advantages and Drawbacks of Paraffin and Frozen Tissues
- Fixation and Shipment of Tissue Samples for Frozen Downstream Applications
- Fixation and Shipment of Wet Tissues for Paraffin Embedding Downstream Services
- Why More Organizations are Outsourcing Histopathology
- Histopathology for Oncology Therapeutics
- Resin Histology by Device Type (Cut & Grind vs. Microtomy)
- Histopathological Considerations for IHC-based Studies
- Fixing Tissue for Optimal Results: Part II
- Fixing Tissue for Optimal Results: Part 1
- Conducting an IHC Study - Factors to Consider: Part II
- Conducting an IHC Study - Factors to Consider: Part 1
- The Histological Analysis of Implantable Medical Devices
- Conducting Biocompatibility Testing for a Medical Device: Part II
- Conducting Biocompatibility Testing for a Medical Device: Part I
- Challenges Faced by Medical Device Companies: Part II
- Challenges Faced by Medical Device Companies: Part I
- Biocompatibility of Implants/Medical Devices
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